Top 5 Hydroxyapatite Toothpastes of 2025 (Dentist-Approved Review)
If you're searching for the best hydroxyapatite toothpaste, you're not alone. In 2025, more people than ever are ditching fluoride and switching to hydroxyapatite — a safe, effective, and enamel-rebuilding ingredient originally developed by NASA.
Hydroxyapatite is clinically proven to:
- Remineralize enamel
- Reduce sensitivity
- Whiten teeth gently
- Be completely non-toxic (even if swallowed)
After reviewing dozens of options, here are the top 5 hydroxyapatite toothpastes of 2025 — including what sets each one apart.
1. MILTODENT Premium Hydroxyapatite Toothpaste
Best Overall for Sensitivity, Whitening, and Enamel Repair
MILTODENT stands out as the most potent and best-tasting hydroxyapatite toothpaste available today. Formulated by a dentist, it contains an industry-leading 15% micro-hydroxyapatite — significantly higher than most other brands — making it ideal for those looking to strengthen enamel, reduce sensitivity, and brighten their smile without peroxide or fluoride.
Why It’s #1:
- 15% micro-hydroxyapatite (not nano)
- Fluoride-free and peroxide-free
- SLS-free (gentle on sensitive mouths)
- Natural oils like tea tree, peppermint, and menthol
- Deliciously fresh taste without artificial sweeteners
- Made with dentist oversight
Perfect for: Anyone wanting a high-performance, natural toothpaste with noticeable results in sensitivity, whiteness, and overall oral health.
Where to buy: miltodent.com
2. Boka Ela Mint Toothpaste
Boka is one of the most recognized names in the hydroxyapatite space, known for their minimalist formula and smooth flavor. It uses nano-hydroxyapatite (n-Ha), which is widely researched — although some users prefer the safety of non-nano alternatives.
Pros:
- Nano-hydroxyapatite remineralization
- Simple flavor and clean formula
- Sleek packaging
Cons:
- Lower HAp concentration than MILTODENT
- Nano particles raise concern for some users
3. Davids Sensitive + Whitening Toothpaste
Davids has recently entered the remineralization space with its "Sensitive + Whitening" version that includes hydroxyapatite. It’s EWG-certified and packaged in aluminum, appealing to eco-conscious users.
Pros:
- Natural and eco-friendly
- EWG-verified
- Subtle mint flavor
Cons:
- Lower HAp percentage
- No subscription option
4. Wellnesse Remineralizing Toothpaste
Wellnesse offers a wholesome hydroxyapatite formula, especially appealing to families and natural living advocates. It's coconut-based and infused with clays and oils.
Pros:
- Clean label and natural ingredients
- Clay-based detox support
- Affordable price
Cons:
- Grittier texture
- Mild remineralization effect
5. RiseWell Natural Toothpaste
RiseWell uses nano-hydroxyapatite and natural flavors for a clean, gentle brushing experience. Its flavor tends to be lighter, and the texture is very smooth.
Pros:
- Nano-hydroxyapatite
- Essential oil-based flavor
- Kid-friendly version available
Cons:
- Taste may be too mild for some
- Lower HAp content than premium options
Final Thoughts
If you’re looking to switch to a fluoride-free toothpaste that actually repairs enamel, hydroxyapatite is your best bet.
And among the current market leaders, MILTODENT delivers the most concentrated, dentist-formulated solution — with a noticeably fresher taste, no harsh chemicals, and stronger results.
Ready to switch? Try MILTODENT today at www.miltodent.com
Frequently Asked Questions
Is hydroxyapatite better than fluoride?
Studies show that hydroxyapatite is just as effective as fluoride at remineralizing enamel — but without the toxicity risks, making it ideal for both adults and kids.
Can it whiten teeth too?
Yes — hydroxyapatite fills microscopic holes in enamel, which naturally brightens and smooths the surface without peroxide.
Is MILTODENT safe for daily use?
Absolutely. MILTODENT is free from SLS, fluoride, peroxide, and artificial sweeteners — designed for daily use even in sensitive mouths.